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Bio-film Model - Antiviral Services | Creative Diagnostics In natural habitats, bacterial cells often form biofilms to structurally organize and protect their communities. A biofilm is an aggregate of microbial cells that adhere to a live/nonliving surface, and the adherent cells in biofilms are enclosed in a self-produced matrix of extracellular polymeric substances (EPS), including nucleic acids, proteins, polysaccharides, and lipids.