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Cancer of Carcinoma of unknown primary origin in 2022 unknown primary cancer is easy to identify, as their symptoms unknown primary cancer will have alerted their doctor to the likely cause, and this will have been confirmed by the tests done at the hospital. In people with an unknown primary tumour, the tests will have found evidence of a secondary cancer but will not have been able to identify the site of the primary cancer. Some types of secondary cancers from unknown primaries are responsive to treatment, and you may be offered chemotherapy, hormonal therapy, or radiotherapy, alone or in combination.