The flight distance depends upon the departure city you select during the trip to Detroit. Many of the major airlines offer cheap flights to Detroit which takes 45 minutes to many hours. If you book a flight from Chicago to Detroit it takes around 45 minutes to an hour, while a flight from Los Angeles takes about 4 hours and 50 minutes. Meanwhile, from Houston, it took three hours and from Orlando, you will reach in 2 hours and 50 minutes.