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Upadacitinib (Rinvoq) is an oral Janus kinase (JAK) inhibitor indicated for the treatment of several immune-mediated inflammatory disorders, including rheumatoid arthritis, psoriatic arthritis, atopic dermatitis, ulcerative colitis, Crohn's disease, ankylosing spondylitis, and other approved conditions in appropriate patients. It is available as extended-release tablets (15 mg, 30 mg, and 45 mg) and an oral solution (1 mg/mL). The recommended dosage varies according to the specific indication, disease severity, and treatment phase; patients should follow the prescribed dosing regimen outlined in the approved prescribing information.