Category: Technology

https://www.creative-biolabs.com/car-t/adoptive-transfer-of-nk-cells.htm ">adoptive transfer of NK cell Because NK cells do not need to contact or recognize specific tumor antigens in advance, their activity must be highly regulated to limit their response to healthy tissues. The first is to inhibit the expression of receptors. The receptors encoded by these strains are divided into three main types: 1) killer immunoglobulin-like receptor (KIR), 2) c-lectin, NKG2A/CD94, and 3) leukocyte immunoglobulin-like receptor (LILR). The ligands for these inhibitory receptors are commonly expressed major histocompatibility class-I molecules (MHC-1). When MHC-1 molecules bind to inhibitory receptors expressed in NK cells, they provide inhibitory signals to NK cells, preventing their activation, degranulation blocking and cytokine production. Because healthy cells express normal levels of MHC-1 molecules, this mechanism can be used as a form of tolerance of NK cells and protect healthy tissue from NK cells killing. During the development of NK cells, inhibitory receptor ligation with cognate MHC-I can also be used as a mechanism to "educate" NK cells to respond to MHC-I deficient cells. However, this is not the only mechanism that regulates the activity of NK cells.