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Peripheral neuropathic pain Peripheral neuropathic pain is pain that occurs in the nerves outside of the spinal cord, such as those in your wrists, when you have carpal tunnel syndrome, or your skin, in the case of diabetic neuropathy. . It can come from: a problem with the body (which affects the whole body), such as in diabetes alcohol abuse side effects of a chemicals (in which a toxic environment is created for the nerves) a more specific problem, such as a tumor on a nerve a traumatic injury to a nerve The causes Central neuropathic pain occurs in the brain or in the spinal cord, such as pain that is experienced after a spinal cord injury or stroke. In both peripheral pain and central pain, the problem is a malfunction (they don't work as they should) of the nerves themselves. This causes them to transmit pain signals without any real cause.