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What Is a 5in1 Fractional CO2 laser machine? A 5in1 Fractional CO2 laser machine is a multi-functional medical device, which combines CO2 laser technology and fractional ablation principles. Different from the traditional CO2 lasers which emit a continuous beam, fractional lasers divides the beam into thousands of tiny beams (micro-hot areas). This results in a “partial” thermal damage mode, which keeps the surrounding tissue intact, so as to heal faster and minimize downtime. Definition Source: According to the report of Laser Focus World, fractional lasers aims to “provide controllable thermal damage to the skin while protecting healthy tissue, so as to achieve faster recovery and reduce side effects.”