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While sleeping, our skin goes into maintenance mode and this is the best time to maximise hydration. It is also the time when active ingredients can penetrate into the deeper layers of the skin, says Massachusetts-based board-certified dermatologist Dr. Ranella Hirsch. But not all night creams for oily skin and pimples are created equal. If you have oily skin, choosing a suitable formula is key to avoid clogged pores and breakouts.