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Difference Between SAP Hana And SAP S4 Hana Running on top of SAP HANA is SAP S4 HANA, the company's next-generation business suite. SAP HANA is an in-memory database management system (RDBMS). While S/4HANA transforms business processes by offering real-time insights, an improved user experience, and sophisticated functions for enterprise administration, HANA concentrates on database performance. To know more about it join SAP S4 HANA Course.