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Zantac Cancer Lawsuit: Eligibility & Settlement Guide The Zantac Cancer Lawsuit has garnered widespread attention in recent years due to concerns over the safety of Zantac, a once-popular heartburn medication. Zantac, which contains the active ingredient ranitidine, was used by millions of people worldwide to treat conditions like acid reflux, ulcers, and GERD (gastroesophageal reflux disease).