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What is Osteoporosis Bone cancer symptoms, Diagnosis & Causes Of Osteoporosis The primary sign for bone cancers is pain that is usually felt at the site where the tumour is. The pain could last for several months before it becomes severe enough for the patient to seek treatment or it could develop abruptly. The first sign that bone cancer has developed is fracture or a fracture that occurs spontaneously (without any trauma) or as a result of minor injuries that will not fracture bone that is healthy. While Ewing’s sarcoma may have an obvious genetic link but doctors have no idea of the risk factors that contribute to and the causes of other types of bone cancer that are primary. The exposure to radiation, for instance the use of radiation therapy to treat different types of cancer, increases the risk of osteosarcoma. There is no known method to stop osteosarcoma.