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The time within which withdrawal symptoms start depend on the formulation of oxycodone taken and the method it was taken. Immediate-release formats have a half-life of 3-4 hours, for example, while extended-release oxycodone has a longer half-life of around 12 hours, the journal Clinical and Translational Oncology reports. Injecting, snorting, or smoking oxycodone also may send more rapidly into the bloodstream. Even when you take the recommended dose of oxycodone, you can experience side effects such as confusion, drowsiness, constipation, and nausea. If you take too much oxycodone, the side effects can become very serious. more info visit https://robustpharma.com/pain-releif/oxycodone/