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Tadafem Tadafem is a medication that is commonly used to treat erectile dysfunction (ED) in men. It contains Tadalafil as its active ingredient, which is the same active substance found in medications like Cialis. Tadalafil belongs to a class of * called PDE5 inhibitors, which help relax the blood vessels in the penis and increase blood flow, aiding in the achievement and maintenance of an erection when sexually stimulated.