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Penile Cancer Symptoms, Signs & Treatment - Bumps On Penile HPV penile cancer is a group of viruses that can cause warts on or around your genitals. Some types of HPV can lead to penile cancer if you have them for years without treatment. It’s passed from one person to another during or other intimate skin-to-skin contact. There are vaccines for boys and girls that help protect against HPV infections, but they aren’t given after age 26. The treatment of cancer cells with anti-cancer (cytotoxic) medicines. It might be a single medicine or a combination of substances. It is not usually used to treat penile cancer. Chemotherapy cream may be used to treat extremely tiny, early malignancies of the foreskin and penis (glans).