Nexgard + Heartgard Plus Combo Pack is specially made to address the concerns of fleas, ticks, mites, worms, and heartworms in dogs. With the power of Afoxolaner, Nexgard treats and controls flea, tick, and mite infestations, whereas Heartgard Plus protects against heartworm and intestinal worm infections. The combo pack works effectively for one full month in protecting your dog against various external and internal parasites.