Ideally, a psilocybin microdose will not cause a substantial change in mood, disposition, or mindset. Instead, its effect will be subtle but present.

Preparing psilocybin mushrooms for microdosing involves more steps than microdosing, but is still straightforward.

Not only will fresh and dried psilocybin mushrooms contain different quantities of psilocybin, but different strains of mushrooms will have different psilocybin contents. Even different parts of the mushroom contain slightly different amounts of psilocybin!