2C-B Powder, 2C-E, and 2C-B are all psychedelic in the 2C class that has recently become popular. 2C-B Powder: These synthetic substances mimic the effects of common illicit but have been designed to bypass laws against similar intoxicants. 2C-B was outlawed in many nations in the late 1990s or early 2000s, only to be replaced with 2C-E and 2C-I, both of which were recently classified as Schedule I controlled substances in the US.