Connections is one of the early pioneers in pushing sunlight based water radiator framework since 1977. and furthermore gives items, for example, thermomax, pytha, Edwards Solar Heater and Hot Water Solar System in Singapore.

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AKG additionally has corporate investigation in Singapore which contains a comprehensive scope of administrations that incorporate background check-ins, employee check-ins and accounting forensics. Our group's wide scope of aptitude and experience guarantees faithful examinations led in an expert way.

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Bcl-2 Family Inhibitors, Agonists and Modulators - BOC Sciences
There are a total of 25 genes in the Bcl-2 family known to date. These proteins is known as an important gatekeeper to the apoptotic response. This group of structurally related proteins comprises pro-apoptotic and anti-apoptotic members that interact with one another.

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ATR Inhibitors, Agonists and Modulators - BOC Sciences
Ataxia telangiectasia mutant gene Rad3 associated kinase (ATR) is an important regulatory factor for the mechanism of DNA damage repair (DDR). ATR is a member of phosphatidylinositol 3-kinase associated kinase protein family. It consists of 2644 amino acids, and its N-terminal is ATR interaction protein (ATR-interacting-protein, ATRIP) binding domain, which is an important domain activated by ATR.

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ATPase/GTPase Inhibitors, Agonists and Modulators - BOC Sciences
ATPases are a class of enzymes that catalyze the decomposition of ATP into ADP and a free phosphate ion. This dephosphorylation reaction releases energy, which the enzyme (in most cases) harnesses to drive other chemical reactions that would not otherwise occur.

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ATP Citrate Lyase Inhibitors, Agonists and Modulators - BOC Sciences
ATP citrate lyase is an enzyme that in animals represents an important step in fatty acid biosynthesis. This step in fatty acid biosynthesis occurs because ATP citrate lyase is the link between the metabolism of carbohydrates (which causes energy) and the production of fatty acids. In plants, ATP citrate lyase generates cytosolic acetyl-CoA precursor of thousands of specialized metabolites including waxes, sterols, and polyketides.

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ATM Inhibitors, Agonists and Modulators - BOC Sciences
The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an apical activator of the DNA damage response in the face of DNA double-strand breaks (DSBs). Following induction of DSBs, ATM mobilizes one of the most extensive signalling networks that responds to specific stimuli and modifies directly or indirectly a broad range of targets.

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Bradykinin Receptor Inhibitor

The bradykinin receptor family is a group of G-protein coupled receptors whose principal ligand is the protein bradykinin. There are two Bradykinin receptors: the B1 receptor and the B2 receptor. Bradykinin receptor B1 (B1) is a G-protein coupled receptor encoded by the BDKRB1 gene in humans.

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Chromogranin A / Pancreastatin - Creative Peptides
Cat. # Product Name Price
P01002 Pancreastatin, porcine Inquiry
P01006 Pancreastatin [Tyr0], porcine Inquiry
P01001 Pancreastatin (33-49), porcine Inquiry
P01007 Pancreastatin (33-48) (human) Inquiry

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Oligopeptide Synthesis - Creative Peptides
As the world's largest producer of synthetic peptides, Creative Peptides’ peptide synthesis process, peptide production equipment and expertise enable us to provide high-volume, high-quality custom oligopeptides, providing our customers with a degree of flexibility to ensure final product delivery.

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Glycyl Tyrosine - Creative Peptides
Glycyltyrosine is a dipeptide composed of glycine and tyrosine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.

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Alanyl Glutamine - Creative Peptides
Alanylglutamine is a nutritional supplement containing a stable, water-soluble dipeptide comprised of the amino acids L-glutamine and L-alanine, with potential protective and absorption enhancing activities.

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Matrix Metalloproteinase (MMP) Inhibitors & Substrates - Creative Peptides
Cat. # Product Name Price
M3001 Z-Pro-Leu-Gly-NHOH Inquiry
M3006 Z-Pro-Leu-Ala-NHOH Inquiry
M3007 Z-Pro-D-Leu-D-Ala-NHOH Inquiry
M3004 Peptide 74 Inquiry
M3117 Mca-(Ala7,Lys(Dnp)9)-Bradykinin Inquiry

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Insulin-Like Growth Factors (IGF), Fragments & Related Peptides - Creative Peptides
The insulin-like growth factors (IGF) is a group of polypeptides with growth-promoting effects. The secretory cells are widely distributed in tissues such as liver, kidney, lung, heart, brain and intestine. The IGFs family consists of two low molecular peptides (IGF-I, IGF-II), two types of specific receptors including IGF-IR and IGF-IIR, and six binding proteins (IGF binding proteins, IGFBP), in which the IGF-I, IGF-II play an active role in cell proliferation and exist in association with distinct and specific IGF-binding proteins designated as IGFBPs 1–6 and possibly IGFBP-related proteins (IGFBP-rPs).

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Exendins and Fragments - Creative Peptides
Cat. # Product Name Price
CAD-110 Endo-38a-Pro-Exenatide Inquiry
E10012 Trp Cage Inquiry
E10011 Glicentin-Related Peptide (21-50), human Inquiry
E10005 Exendin-4 (3-39) Inquiry
E10013 Exendin-4 (1-8) Inquiry
E10002 Exendin-4 Inquiry
E10003 Exendin-3 Inquiry
E10001 Exendin (9-39) Inquiry
E10010 Exendin (7-39) Inquiry
E10009 Exendin (5-39) Inquiry
E10008 Exendin (4-39) Inquiry

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Eye Care - Creative Peptides
If you are still hesitate with Acetyl hexapeptide-3, there are some other options from Creative Peptides, such as Acetyl Tetrapeptide-5(CPC1610), Dipeptide-2 (CPC1652) and Palmitoyl Tetrapeptide-7(CPC1626). Acetyl Tetrapeptide-5 is a tetrapeptide with reducing water accumulation properties which been tested in 20 volunteers.

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Antifungal Inhibitors, Agonists and Modulators - BOC Sciences
Antifungal inhibitors are available at BOC Sciences.

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ICOS Inhibitors - BOC Sciences
ICOS plays a dual role in tumor immunity. On the one hand, ICOS can promote the proliferation of CD8 T cells and the production of cytokines such as IL-2, thereby enhancing the anti-tumor immune effect; on the other hand, ICOS inhibits tumor immunity by inhibiting CD4 T proliferation through IL-10/TGF-β. The immunomodulation targeting ICOS pathway has important clinical significance in the development of long-term tolerance including autoimmune diseases and transplantation immunity.

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VISTA Inhibitors - BOC Sciences
The V-domain Ig suppressor of T cell activation (VISTA) also known as PD-1 homolog (PD-1H) was described as a negative checkpoint regulator in the IgSF structurally related to CTLA-4 and PD-1. VISTA is highly expressed on tumor-infiltrating leukocytes.

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BTLA Inhibitors - BOC Sciences
The immune response of the organism is regulated by the activation and suppression signals. BTLA and its activated signal pathway mainly exert immunosuppressive effect in cellular and humoral immunity, induce immune tolerance, and is closely related to the occurrence and development of autoimmune diseases such as rheumatoid arthritis, AIDS and other infectious diseases, as well as tumor and graft versus host disease, etc. The regulation of BTLA signaling pathway is expected to be used for immunotherapy of related diseases.

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T-cell immunoglobulin and mucin domain 3 (TIM3) is a molecule selectively expressed on T helper 1 (Th1) cells. It is an immune checkpoint receptor that suppresses the activation of Th1 cells on engagement with its ligand, galectin-9.

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OX40 (also known as CD134) Inhibitors - BOC Sciences
BOC Sciences Company is pleased to provide you with quality OX40 antibody monotherapy related services. The company has the world's leading pharmaceutical and biotechnology R & D laboratory. Over the years, our experts have been working on OX 40 antibody monotherapy related techniques, and have achieved excellent results. The company sincerely looks forward to working with you hand in hand.

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KIR Inhibitors - BOC Sciences
BOC Sciences Company is pleased to provide you with high quality KIR related services. The company has the world's leading pharmaceutical and biotechnology R & D laboratory. Our experts have been developing KIR-related disease treatment technology for many years, and have achieved excellent results. If you are interested in this, we sincerely look forward to cooperating with you.

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Intermediates - BOC Sciences
As a professional company, BOC Sciences has directed sincere efforts toward providing customers a broad range of quality pharmaceutical intermediates at very competitive costs.

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Cell Penetrating Peptide Design and Synthesis Services - Creative Peptides
Cell penetrating peptides (CPPs), also known as protein transduction domains (PTDs) or membrane transduction peptides (MTPs), are small molecular peptides that consist of 5-30 amino acid residues, which not only penetrate the cell membrane by themselves, but also carry a variety of exogenous substances such as peptides, proteins, nucleic acids and nanoparticles in a covalent or non-covalent binding manner into cells.

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Stable Isotope Labeled Peptides - Creative Peptides
With more than 10 years of experience, and as a world-leading peptide manufacturing organization, Creative Peptides can provide customized peptides labeled with stable isotopes including 2H, 15N & 13C, respectively, or a combination of 15N & 13C. Even when the peptides are attached with specific modification motifs.

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β-and γ-Secretase Inhibitors - Creative Peptides
γ-Secretase is a fascinating, multi-subunit, intramembrane-cleaving protease that is now being considered as a therapeutic target for a number of diseases. Potent, orally bioavailable γ-secretase inhibitors (GSIs) have been developed and tested in humans with Alzheimer's disease (AD) and cancer.

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Immunotherapy-Cell Therapy - Creative Peptides
For the last few decades scientist have been researching the involvement of the immune system in cancer development to discover potential cure. Immune cells has been known to play an important role in regulating tumor progression, thus stimulating immune reactions towards tumors can be an attractive therapeutic targeting cancer. More and more clinical data has been shown positive signs of immunotherapy and cell therapy as potential cure for cancer.

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Peptide-based diabetes mellitus treatment is leading a revolution in the treatment of diabetes due to their multi-functional properties. As the most thriving pharmaceutical companies pursue this booming field of research, it is necessary, more than ever, to have high quality cGMP (current Good Manufacturing Practice) peptides synthesis.

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Antimicrobial Peptides - Creative Peptides
Most AMPs act by provoking an increase in plasma membrane permeability. First step in the mechanism of membrane permeabilization is the electrostatic interaction between the positively charged AMP with the negatively charged membrane surface of the microorganism. Subsequent disruption of the membrane by creation of pores within the microbial membrane ultimately results in cell death of the organism due to leakage of ions, metabolites, cessation of membrane-coupled respiration, and biosynthesis. The mechanics of AMPs represent an unusual source for the targeted exploration of new applications in the therapy of microbial and viral infection, cancer, and sepsis.

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